Mumbai is commercial capital of India and itself can be visited for a luxurious weekend. Juhu beach (Western Suburbs - North Mumbai) and surrounding areas are good for shopping and nightlife (Pubs, Discos and Restaurants). Colaba around Gateway of India in South Mumbai lends a heritage touch and has number of promenades, heritage structures (Gateway of India etc.) and good number of high end Restaurants for a luxurious weekend.

Resort and Retreat are two resorts just off the main city at Madh / Marve which can be considered a Getaway resorts. 

If 2 hour plus drive is ok then Lonavala (110 kms) and Beach Getaways (Alibaug / Kashid / Murud - 120 - 150 kms) are two popular getaways from Mumbai.

Mumbai is also an access point for visiting various temples around Maharashtra e.g. Ashtavinayak 

Ex-Mumbai adventure activities have picked up and now there are several adventure oriented resort stays that offer White water rafting besides other adventure activites e.g. Empower Camp.

For Full List of resorts, farms, adventure getaways around Mumbai - Beach Getaways | Weekend Retreats | Hill Stations | Adventure / Nature / Private Farms | Religious Destinations 

Short Break and Holiday Ideas / Itineraries Ex-Mumbai

Nashik - Shirdi - Aurangabad - 4 nights

Daman - Silvassa - 4 nights

Hill Stations - Bhandardara - Saputara - 4 nights

Hill Stations - Matheran - Panchgani/Mahabaleshwar - 4 nights

Coastal Circuit : Kashid -Chiplun - 4 nights

Coastal Circuit with Hills : Kashid -Chiplun- Mahabaleshwar / Panchgani - 6 nights

Coastal Circuit : Ganapatipule -Chiplun- (Ex-Mumbai / Ex-Pune / Ex-Goa) - 4 nights

Ashtavinayak with Shirdi, Trimbakeshwar and Shani Temple Ashtavinayak - 1 night - 2 days Itinerary Ashtavinayak - 2 nights - 3 days Itinerary

- Itinerary also suited for honeymooners